Isocitrate dehydrogenase kinase/phosphatase: identification of mutations which selectively inhibit phosphatase activity
نویسندگان
چکیده
منابع مشابه
Isocitrate dehydrogenase mutations in leukemia.
Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the neomorphic, oncogenic function of IDH muta...
متن کاملIsocitrate dehydrogenase kinase/phosphatase: aceK alleles that express kinase but not phosphatase activity.
For Escherichia coli, growth on acetate requires the induction of the enzymes of the glyoxylate bypass, isocitrate lyase and malate synthase. The branch point between the glyoxylate bypass and the Krebs cycle is controlled by phosphorylation of isocitrate dehydrogenase (IDH), inhibiting that enzyme's activity and thus forcing isocitrate through the bypass. This phosphorylation cycle is catalyze...
متن کاملMolecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer.
IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. The mutant protein loses its n...
متن کاملThe Role of Isocitrate Dehydrogenase Mutations in Glioma Brain Tumors
Isocitrate dehydrogenases (IDHs) are enzymes long known to biologists as a component of the tricarboxylic acid (TCA) cycle that converts isocitrate to α-ketoglutarate (α-KG) with production of NADH and/or NADPH. However, it was mainly viewed as a “housekeeping” gene by cancer biologists with no previously defined role in cancer. This changed in 2008 with the discovery that IDH1 was frequently m...
متن کاملIsocitrate dehydrogenase mutations: new opportunities for translational research
Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma. These alterations are closely associated with the pro...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1992
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.174.4.1414-1416.1992